The Oxford Handbook of Clinical Immunology and Allergy is a practical and clinically relevant guide to assist with the diagnosis and management of immunological/allergic disease, and the correct selection and interpretation of immunological tests. This new edition reflects the significant developments that have occurred in the field over recent years. Major revisions have been made to the section on primary immunodeficiencies to demonstrate the advances in understanding genetics, tissue typing, and therapeutics. The first section covers clinical diseases, including primary and secondary immunodeficiencies, allergic disease, autoimmunity and connective tissue diseases, and vasculitis. It gives guidance on test selection and interpretation for both diagnosis and monitoring. The second section covers diagnostic tests, summarizing the methodology and pros and cons of each.